It really depends on which features of the Seeed Sensor board you need to work!
Getting the level-shifted GPIO working is fairly easy. In fact it was discussing during one of the recent open hours Q&A sessions. Watch the video and see what you think.
It should also be possible to gain access to the level shifted I2C (I2C0 and I2C1) peripherals using a similar permissions trick. However you will probably also have to compile i2ctools either using termux (on the device) or NDK (on the host PC).
Getting the microcontroller working is technically possible. Its wired up using a serial port but you need a lot of software to make it work. You would end up having to cross-compile the AVR toolset and write an altenative IDE…