Thanks for your reply.
I have had no issues using I2C 0 and 1 which are available on the LS expansion connector. I am however trying to utilize I2C 2 and 3 which are on the HS expansion connector of the dragonboard.
The sample project referenced above also only detects I2C 0 and 1.
My thinking is that the BLSP’s where I2C 2 and 3 are located are not configured in I2C mode. From my research it is quite straight forward to enable this in the device tree when using Linux/android, but I have not found any info/documentation on how to do this for Windows IOT.